The Mission of Neuroendocrinology and Aging Group is to contribute to develop new knowledge in the aging field, namely to demonstrate that neuroendocrine system and related mechanisms can be targeted in experimental models to delay, stop, and in some examples, reverse manifestations of aging and age-related disorders.
The knowledge generated by our group has been contributing to the hypothesis that aging and age-related disorders could be controlled by using neuroendocrine strategies. These strategies are based on targeting the main brain area involved in the neuroendocrine system - the hypothalamus -, its main functions (circadian rhythm, sleep, food intake, metabolism), and also the hypothalamus-periphery axis.
The group members have complementary expertise: establishment of cellular and animal models of aging and age-related disorders (progeria, neurodegenerative disorders, OSA, OA, insomnia, metabolic dysfunction and obesity), evaluation of physiology, cellular and molecular aging markers (namely autophagy, senescence, inflammation), gene transfer approaches, circadian rhythm analysis, medicinal chemistry and histopathological methodologies. Moreover, the group has expertise to organize pre-clinical studies and public engagement activities.
NiNjA - New Neuroendocrine strategy for healthy Aging. FCT - Fundação para a Ciência e Tecnologia. PI: Claudia Cavadas, Co-PI: Célia Aveleira.
noOSAnoAGEING - Obstructive Sleep Apnea early diagnosis as a new strategy to delay ageing. FCT - Fundação para a Ciência e Tecnologia. PI: Ana Rita Álvaro; Co-PI: Claudia Cavadas; Co-PI: Célia Aveleira.
Neuroendocrine strategies to delay aging - Nutrient sensing and food intake as intervention strategies WP5. COMPETE 2020. PI of WP: Cláudia Cavadas.
CARTILFACTORY - Development and Construction of an Automated Large Scale Manufacturing System for Cartilage Engineering Combining 3D Electroplating of Chondrocytes and 3D Cellular Expansion with Mechanical Stimulation in Bioreactor. COMPETE 2020. PI of WP: Alexandrina F Mendes.
COST Action: An integrative action for multidisciplinary studies on cellular structural networks. COST Action. National representative: Cláudia Cavadas.