Healthy Living and Active Ageing

João Malva

PhD, Principal Investigator

The Healthy Living and Active Ageing research group has been inspired by the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) and by Ageing@Coimbra Consortium (EIP on AHA Reference Site) to deliver innovative knowledge transfer on ageing research and good practices to support healthy living and better health care.

The key objectives of the research group are addressed the three inspiring questions:

  1. Why we age?
  2. How we age?
  3. How we support healthy living and active ageing?

The specific objectives enclose:

  1. To understand the impact of inflammation and stem cell dynamics in physiological ageing;
  2. To identify common mechanisms related with inflammation and stem cell dynamics in age-related chronic diseases;
  3. To develop good practices and technologies supporting healthy living and active ageing;
  4. To empower citizens towards the adoption of adequate health management skills and healthy lifestyles. The mainstream topics enclose fundamental and translational research related with the most prevalent age-related chronic conditions, including: neurodegenerative diseases; musculoskeletal diseases; respiratory diseases, immunology, cardiovascular diseases, diabetes, cancer, adherence to therapy and polymedication, falls and frailty, integrated care and palliative care.

The research team is highly interdisciplinary and encloses fundamental and applied research, medical, nursing and pharmaceutical care, ehealth, health literacy and citizens empowering skills. The members of the team have been founders and coordinators of Ageing@Coimbra; members of EIT Health Knowledge Innovation Community (KIC); coordinators of RESOE (North-West Iberian regional cluster) task force on Demographic Changes and Ageing; members of coordination board of the Reference Site Collaborative Network; coordinators of relevant scientific societies (eg. Neuroscience, Internal Medicine (including Geriatrics), Rheumatology, Forensic Medicine, Atherosclerosis, among others).

Group Members

Group members are: João Malva (PhD, Principal Investigator), Ana Costa (MD, PhD), Ana Marta Lavrador, Anabela Mota Pinto (MD, PhD), Barbara Silva (PhD), Carlos Cordeiro (MD, PhD), Cláudia Loureiro (MD, PhD), Diogo Fonseca (PhD), Duarte Nuno Vieira (PhD), Helder Esperto (MD), Isabel Pereira (PhD), João Mendes, José Silva (MD, PhD), Manuel Veríssimo (PhD).

Selected Publications

The Quadruple Helix-Based Innovation Modelo f Reference Sites for Active and Healthy Ageing in Europe: The Ageing@Coimbra Case Study. Malva JO, Amado A, Rodrigues A, Mota-Pinto A, Cardoso AF, Teixeira AM, Todo-Bom A, Devesa A, Ambrósio AF, Cunha AL, Gomes B, Dantas C, Abreu C, Santana I, Bousquet J, Apóstolo J, Santos L, Meneses de Almeida L, Illario M, Veríssimo R, Rodrigues V and Veríssimo MT (2018). Front Med (In Press).

Impact of Neuroinflammation on Hippocampal Neurogenesis: Relevance to Ageing and Alzheimer’s Disease. Valero J, Bernardino L, Cardoso F, Silva AP, Fontes-Ribeiro C, Ambrósio AF and Malva JO (2017) J. Alzheim. Dis. J Alzheimers Dis. 60(s1):S161-S168. doi: 10.3233/JAD-170239

Urinary metabolomic profiling of asthmatics can be related to clinical characteristics. Loureiro CC, Oliveira AS, Santos M, Rudnitskaya A, Todo-Bom A, Bousquet J and Rocha SM (2016) Allergy 61: 1362-1365. DOI: 10.1111/all.12935

Past trends and projections of hospital deaths to inform the integration of palliative care in one of the most ageing countries in the world. Sarmento VP, Higginson IJ, Ferreira PL, Gomes B (2016) Palliative Medicine 30: 363-373. doi: 10.1177/0269216315594974

Long-term effects of an acute and systemic administration of LPS on adult neurogenesis and spatial memory. Valero J, Mastrella G, Neiva I, Sánchez S and Malva JO. (2014) Front Neurosci. 8:83. doi: 10.3389/fnins.2014.00083

Selected Grants

ERA@UC – Enhancing Ageing Research at the University of Coimbra; H2020 Widespread-2014-2 ERAChairs; 669088 ERA@UC; 2.486.165€; 2015-2020 (PI João Malva)

MIA – Multidisciplinary Institute of Ageing; H2020 Widespread-2014-1 Teaming; 664628 MIA; 499.232€; 2015-2016 (PI João Malva)

SIMPATHY – Stimulating Innovation Management of Polypharmacy and Adherence in the Elderly; H2020 HP-PJ 2014; 663082 SIMPATHY; 123.906€ (UC budget); 2015-2017 (PI at UC João Malva; coordinator Scottish Government)

HeaLIQs4Cities - Healthy Lifestyle Innovation Quarters for Cities and Citizens; EIT Health Campus for Citizens project 18036; 67.000€ (2018-2018) (PI at UC João Malva)

CARE - Caregiving and Ageing Reimagined in Europe; EIT Health Campus for Executives and Professionals project 18256; 36.000€ (2018-2018) (PI at UC João Malva and Bárbara Gomes)